Recombinant Human TNF receptor-associated factor 2 (TRAF2)

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• Catalog number
  MBS1364100
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• Size
  1 mg (Yeast)

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• Products_type
  Recombinant Protein
• Products_short_name
  [TNF receptor-associated factor 2 (TRAF2)]
• Other_names
  [TNF receptor-associated factor 2; TNF receptor-associated factor 2; TNF receptor-associated factor 2; TNF receptor associated factor 2; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2Curated; Tumor necrosis factor type 2 receptor-associated protein 3]
• Products_gene_name
  [TRAF2]
• Products_gene_name_syn
  [TRAF2]
• Other_gene_names
  [TRAF2; TRAF2; TRAP; TRAP3; RNF117; MGC:45012; TRAP3]
• Purity
  >85% (SDS-PAGE)
• Form
  Lyophilized or liquid (Format to be determined during the manufacturing process)
• Storage_stability
  Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

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• Gene target
  TNF   receptor-associated   factor   TRAF2  
• Gene symbol
  TNF, TNFRSF1A, TRAF2, TANK, TNFRSF1B, LTBR
• Short name
  Recombinant TNF receptor-associated factor 2 (TRAF2)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  E Coli or Yeast or Baculovirus or Mammalian Cell
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens tumor necrosis factor receptor-associated factor 2 (tumor necrosis factor receptor-associated factor 2)
• Alternative technique
  rec
• Alternative to gene target
  TNF receptor-associated factor 2, MGC:45012 and TRAP and TRAP3, TRAF2 and IDBG-92817 and ENSG00000127191 and 7186, metal ion binding, Plasma membranes, Traf2 and IDBG-146254 and ENSMUSG00000026942 and 22030, TRAF2 and IDBG-641438 and ENSBTAG00000010497 and 512355

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:12032
• Gene
  TRAF2
• Long gene name
  TNF receptor associated factor 2
• Synonyms
  • TRAP3
  • RNF117
• GenBank acession
  • U12597
• Locus
  9q34.3
• Discovery year
  1999-04-28
• Entrez gene record
  7186
• Pubmed identfication
  • 7639698
• RefSeq identity
  • NM_021138
• Classification
  • TNF receptor associated factors
  • MicroRNA protein coding host genes
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000020952

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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